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KMID : 0043320090320040515
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Archives of Pharmacal Research
2009 Volume.32 No. 4 p.515 ~ p.520
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New Anthracene Glycosides from Rhodomyrtus tomentosa Stimulate Osteoblastic Differentiation of MC3T3-E1 Cells
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Kim Young-Ho
Minh Chua Van
Kiem Phan-Van
Choi Eun-Mi
Ding Yan
Tung Nguyen Huu
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Abstract
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Two new anthracene glycosides (1, 2) were isolated from aerial parts of Rhodomyrtus tomentosa, along with three known compounds (3-5). The structures of two new compounds were established to be 4,8,9,10-tetrahydroxy-2,3,7-trimethoxyanthracene-6-O-β -D-glucopyranoside (1) and 2,4,7,8,9,10-hexahydroxy-3-methoxyanthracene-6-O-α-L-rhamnopyranoside (2) based on spectroscopic and chemical methods. Among them, compound 1, 2, and 5 significantly (P<0.05) increased the alkaline phosphatase activity, collagen synthesis, and mineralization of the nodules of MC3T3-E1 osteoblastic cells compared to those of the control, respectively.
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KEYWORD
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Rhodomyrtus tomentosa, Myrtaceae, Anthracene glycoside, Osteoblast, MC3T3-E1 cells
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